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Target
5-lipoxygenase
Ligand
BDBM50004677
Substrate
n/a
Meas. Tech.
ChEMBL_3983 (CHEMBL619256)
IC50
500±n/a nM
Citation
 Müller, K; Gürster, D; Piwek, S; Wiegrebe, W Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase. J Med Chem 36:4099-107 (1994) [PubMed]  Article 
Target
Name:
5-lipoxygenase
Synonyms:
Arachidonate 5-lipoxygenase
Type:
PROTEIN
Mol. Mass.:
49994.23
Organism:
Bos taurus
Description:
ChEMBL_157766
Residue:
430
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGDIQLIKIEKRKYWFHDDWYLKYITVKTPCGDYIEFPCYRWISGEGEIVLRDGQAKLACDDQIHVLKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWSDFADFEKIFVRISNTISERVMNHWQEDRMFGYQFLNGCNPVMIQRCLKLPDNLPVTTEMVECSLERQLTLEQEIEQGNIFIVDFKLLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQVPGEENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICEYGLFDKANATGG
  
Inhibitor
Name:
BDBM50004677
Synonyms:
Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-naphthalen-1-yl ester | Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-naphthalen-1-yl ester (Ionapalene) | Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-naphthalen-1-yl ester (lonapalane) | Acetic acid 4-acetoxy-7-chloro-2,3-dimethoxy-naphthalen-1-yl ester | CHEMBL36648 | Lonapalene | RS-43179
Type:
Small organic molecule
Emp. Form.:
C16H15ClO6
Mol. Mass.:
338.74
SMILES:
COc1c(OC)c(OC(C)=O)c2cc(Cl)ccc2c1OC(C)=O
Structure:
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