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Target
Thromboxane A2 receptor
Ligand
BDBM50043843
Substrate
n/a
Meas. Tech.
ChEMBL_209590 (CHEMBL814725)
IC50
33±n/a nM
Citation
 Soyka, R; Heckel, A; Nickl, J; Eisert, W; Müller, TH; Weisenberger, H 6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors. J Med Chem 37:26-39 (1994) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50043843
Synonyms:
(E)-6-Pyridin-3-yl-6-{4-[2-(toluene-4-sulfonylamino)-ethyl]-phenyl}-hex-5-enoic acid | CHEMBL129734
Type:
Small organic molecule
Emp. Form.:
C26H28N2O4S
Mol. Mass.:
464.577
SMILES:
Cc1ccc(cc1)S(=O)(=O)NCCc1ccc(cc1)C(=C/CCCC(O)=O)\c1cccnc1
Structure:
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