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Target
Interleukin-6 receptor subunit beta
Ligand
BDBM50496302
Substrate
n/a
Meas. Tech.
ChEMBL_1296585 (CHEMBL3131105)
Kd
288000±n/a nM
Citation
 Li, H; Xiao, H; Lin, L; Jou, D; Kumari, V; Lin, J; Li, C Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface. J Med Chem 57:632-41 (2014) [PubMed]  Article 
Target
Name:
Interleukin-6 receptor subunit beta
Synonyms:
CD_antigen=CD130 | CDw130 | IL-6 receptor subunit beta | IL-6R subunit beta | IL-6R-beta | IL-6RB | IL6RB_HUMAN | IL6ST | Interleukin-6 receptor subunit beta | Interleukin-6 signal transducer | Membrane glycoprotein 130 | Oncostatin-M receptor subunit alpha | gp130
Type:
PROTEIN
Mol. Mass.:
103525.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108130
Residue:
918
Sequence:
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEGMPKSYLPQTVRQGGYMPQ
  
Inhibitor
Name:
BDBM50496302
Synonyms:
MADINDOLINE A
Type:
Small organic molecule
Emp. Form.:
C22H27NO4
Mol. Mass.:
369.4541
SMILES:
CCCCC1=C(C)C(=O)[C@](C)(CN2C3OCC[C@@]3(O)c3ccccc23)C1=O |c:4|
Structure:
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