Reaction Details Report a problem with these data
Target
Neuraminidase
Ligand
BDBM50497242
Substrate
n/a
Meas. Tech.
ChEMBL_1363526 (CHEMBL3292277)
IC50
46460±n/a nM
Citation
 Lou, J; Yang, X; Rao, Z; Qi, W; Li, J; Wang, H; Li, Y; Li, J; Wang, Z; Hu, X; Liu, P; Hong, X Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors. Eur J Med Chem 83:466-73 (2014) [PubMed]  Article 
Target
Name:
Neuraminidase
Synonyms:
NA | NRAM_I33A0
Type:
PROTEIN
Mol. Mass.:
49687.56
Organism:
Influenza A virus
Description:
ChEMBL_1347422
Residue:
453
Sequence:
MNPNQKIITIGSICMVVGIISLILQIGNIISIWISHSIQTGNQNHTGICNQGIITYNVVAGQDSTSVILTGNSSLCPIRGWAIHSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDNGAVAVLKYNGIITETIKSWRKKILRTQESECTCVNGSCFTIMTDGPSNGLASYKIFKIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIGYICSGVFGDNPRPKDGPGSCGPVSADGANGVKGFSYRYGNGVWIGRTKSDSSRHGFEMIWDPNGWTETDSRFSVRQDVVAMTDRSGYSGSFVQHPELTGLDCMRPCFWVELIRGRPEEETIWTSGSIISFCGVNSDTVDWSWPDGAELPFTIDK
  
Inhibitor
Name:
BDBM50497242
Synonyms:
CHEMBL3290254
Type:
Small organic molecule
Emp. Form.:
C15H16FN3O4
Mol. Mass.:
321.3036
SMILES:
CCOC(=O)C1C(N=C(NC(C)=O)NC1=O)c1ccccc1F |t:7|
Structure:
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