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Target
Platelet-activating factor receptor
Ligand
BDBM50003506
Substrate
n/a
Meas. Tech.
ChEMBL_151692 (CHEMBL760442)
IC50
9.1±n/a nM
Citation
 Carceller, E; Merlos, M; Giral, M; Almansa, C; Bartrolí, J; García-Rafanell, J; Forn, J Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists. J Med Chem 36:2984-97 (1993) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50003506
Synonyms:
CHEMBL322184 | CHEMBL545771 | {4-[2-(Benzhydryl-amino)-acetyl]-piperazin-1-yl}-pyridin-3-yl-acetonitrile; trihydrochloride; hydrate
Type:
Small organic molecule
Emp. Form.:
C26H27N5O
Mol. Mass.:
425.5255
SMILES:
O=C(CNC(c1ccccc1)c1ccccc1)N1CCN(CC1)C(C#N)c1cccnc1
Structure:
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