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Target
Neuronal acetylcholine receptor subunit beta-2
Ligand
BDBM50143313
Substrate
n/a
Meas. Tech.
ChEMBL_1451267 (CHEMBL3362770)
IC50
1200±n/a nM
Citation
 Jepsen, TH; Jensen, AA; Lund, MH; Glibstrup, E; Kristensen, JL Synthesis and Pharmacological Evaluation of DH?E Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists. ACS Med Chem Lett 5:766-70 (2014) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit beta-2
Synonyms:
ACHB2_MOUSE | Chrnb2
Type:
PROTEIN
Mol. Mass.:
57114.19
Organism:
Mus musculus
Description:
ChEMBL_108396
Residue:
501
Sequence:
MARCSNSMALLFSFGLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRLRLRRRQREREGAGTLFFREGPAADPCTCFVNPASMQGLAGAFQAEPAAAGLGRSMGPCSCGLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTATTFLHSDHSAPSSK
  
Inhibitor
Name:
BDBM50143313
Synonyms:
(12S,13aS)-12-Methoxy-1,4,5,6,9,11,12,13-octahydro-8H-pyrano[4',3':3,4]pyrido[2,1-i]indol-2-one | CHEMBL293950 | DHbetaE
Type:
Small organic molecule
Emp. Form.:
C16H21NO3
Mol. Mass.:
275.3428
SMILES:
CO[C@H]1CC=C2CCN3CCC4=C(CC(=O)OC4)[C@]23C1 |t:4,11|
Structure:
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