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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50046488
Substrate
n/a
Meas. Tech.
ChEMBL_201717 (CHEMBL803754)
IC50
282±n/a nM
Citation
 Mewshaw, RE; Sherrill, RG; Mathew, RM; Kaiser, C; Bailey, MA; Karbon, EW Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled sigma binding site. J Med Chem 36:343-52 (1993) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50046488
Synonyms:
8-Fluoro-2-(3-pyridin-4-yl-propyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | CHEMBL442395
Type:
Small organic molecule
Emp. Form.:
C19H20FN3
Mol. Mass.:
309.3806
SMILES:
Fc1ccc2[nH]c3CCN(CCCc4ccncc4)Cc3c2c1
Structure:
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