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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50046448
Substrate
n/a
Meas. Tech.
ChEMBL_201717 (CHEMBL803754)
IC50
>10000±n/a nM
Citation
 Mewshaw, RE; Sherrill, RG; Mathew, RM; Kaiser, C; Bailey, MA; Karbon, EW Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled sigma binding site. J Med Chem 36:343-52 (1993) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50046448
Synonyms:
1N-{2-[9,15-diazatetracyclo[10.2.1.02,10.03,8]pentadeca-2(10),3,5,7-tetraen-15-yl]ethyl}-1N-methyl-2-(3,4-dichlorophenyl)acetamide | CHEMBL117748
Type:
Small organic molecule
Emp. Form.:
C24H25Cl2N3O
Mol. Mass.:
442.381
SMILES:
CN(CCN1C2CCC1c1c(C2)[nH]c2ccccc12)C(=O)Cc1ccc(Cl)c(Cl)c1 |THB:3:4:9.10.11:7.6|
Structure:
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