Reaction Details Report a problem with these data
Target
Thromboxane A2 receptor
Ligand
BDBM50047059
Substrate
n/a
Meas. Tech.
ChEMBL_207650 (CHEMBL811632)
Ki
12±n/a nM
Citation
 Nicolaï, E; Goyard, J; Benchetrit, T; Teulon, JM; Caussade, F; Virone, A; Delchambre, C; Cloarec, A Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists. J Med Chem 36:1175-87 (1993) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50047059
Synonyms:
4-[5-Chloro-1-(3,4-dichloro-benzyl)-1H-benzoimidazol-2-yl]-3,3-dimethyl-butyric acid | CHEMBL17528
Type:
Small organic molecule
Emp. Form.:
C20H19Cl3N2O2
Mol. Mass.:
425.736
SMILES:
CC(C)(CC(O)=O)Cc1nc2cc(Cl)ccc2n1Cc1ccc(Cl)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: