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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
Ligand
BDBM82070
Substrate
n/a
Meas. Tech.
ChEMBL_1520448 (CHEMBL3624577)
EC50
724±n/a nM
Citation
 de la Fuente Revenga, M; Balle, T; Jensen, AA; Frĝlund, B Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations. Eur J Med Chem 102:352-62 (2015) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-4/beta-2
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1520448
Components:
This complex has 2 components.
Component 1
Name:
Neuronal acetylcholine receptor subunit beta-2
Synonyms:
ACHB2_MOUSE | Chrnb2
Type:
PROTEIN
Mol. Mass.:
57114.19
Organism:
Mus musculus
Description:
ChEMBL_108396
Residue:
501
Sequence:
MARCSNSMALLFSFGLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRLRLRRRQREREGAGTLFFREGPAADPCTCFVNPASMQGLAGAFQAEPAAAGLGRSMGPCSCGLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTATTFLHSDHSAPSSK
  
Component 2
Name:
Neuronal acetylcholine receptor subunit alpha-4
Synonyms:
ACHA4_MOUSE | Acra4 | Chrna4 | Neuronal acetylcholine receptor subunit alpha-4
Type:
PROTEIN
Mol. Mass.:
70310.60
Organism:
Mus musculus
Description:
ChEMBL_117154
Residue:
629
Sequence:
MEIGGSGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPESEPGILGDICNQGLSPAPTFCNRMDTAVETQPTCRSPSHKVPDLKTSEVEKASPCPSPGSCHPPNSSGAPVLIKARSLSVQHVPSSQEAAEGSIRCRSRSIQYCVSQDGAASLTESKPTGSPASLKTRPSQLPVSDQTSPCKCTCKEPSPVSPITVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
  
Inhibitor
Name:
BDBM82070
Synonyms:
CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D salicylate | US10667515, Compound (S)-nicotine | US9303017, Nicotine
Type:
n/a
Emp. Form.:
C10H14N2
Mol. Mass.:
162.2316
SMILES:
CN1CCC[C@H]1c1cccnc1 |r|
Structure:
Search PDB for entries with ligand similarity: