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Target
Thymidylate synthase
Ligand
BDBM50049266
Substrate
n/a
Meas. Tech.
ChEMBL_209813 (CHEMBL815678)
IC50
80±n/a nM
Citation
 Hennequin, LF; Boyle, FT; Wardleworth, JM; Marsham, PR; Kimbell, R; Jackman, AL Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent. J Med Chem 39:695-704 (1996) [PubMed]  Article 
Target
Name:
Thymidylate synthase
Synonyms:
TS | TSase | TYSY_MOUSE | Tyms
Type:
PROTEIN
Mol. Mass.:
34957.15
Organism:
Mus musculus
Description:
ChEMBL_1340097
Residue:
307
Sequence:
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
  
Inhibitor
Name:
BDBM50049266
Synonyms:
2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-N-(3-nitro-benzyl)-benzamide | CHEMBL162891
Type:
Small organic molecule
Emp. Form.:
C26H24FN5O5
Mol. Mass.:
505.4977
SMILES:
CN(Cc1cc2c(cc1C)nc(CO)[nH]c2=O)c1ccc(C(=O)NCc2cccc(c2)[N+]([O-])=O)c(F)c1
Structure:
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