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Target
GTPase KRas
Ligand
BDBM50500144
Substrate
n/a
Meas. Tech.
ChEMBL_1546981 (CHEMBL3748084)
Kd
420000±n/a nM
Citation
 Kozakov, D; Hall, DR; Napoleon, RL; Yueh, C; Whitty, A; Vajda, S New Frontiers in Druggability. J Med Chem 58:9063-88 (2015) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50500144
Synonyms:
CHEMBL2086792
Type:
Small organic molecule
Emp. Form.:
C14H16N2OS
Mol. Mass.:
260.355
SMILES:
OC1CCN(CC1)C(=S)c1c[nH]c2ccccc12
Structure:
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