Reaction Details Report a problem with these data
Target
Neuropeptide FF receptor 2
Ligand
BDBM50246649
Substrate
n/a
Meas. Tech.
ChEMBL_1543523 (CHEMBL3750524)
Ki
>3000±n/a nM
Citation
 Keller, M; Weiss, S; Hutzler, C; Kuhn, KK; Mollereau, C; Dukorn, S; Schindler, L; Bernhardt, G; König, B; Buschauer, A N(?)-Carbamoylation of the Argininamide Moiety: An Avenue to Insurmountable NPY Y1 Receptor Antagonists and a Radiolabeled Selective High-Affinity Molecular Tool ([(3)H]UR-MK299) with Extended Residence Time. J Med Chem 58:8834-49 (2015) [PubMed]  Article 
Target
Name:
Neuropeptide FF receptor 2
Synonyms:
G-protein coupled receptor 74 | G-protein coupled receptor HLWAR77 | GPR74 | NPFF2 | NPFF2_HUMAN | NPFFR2 | NPGPR | Neuropeptide FF receptor 2 | Neuropeptide G-protein coupled receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60293.78
Organism:
Homo sapiens (Human)
Description:
NPFF2 0 HUMAN::Q9Y5X5
Residue:
522
Sequence:
MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRRLGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
  
Inhibitor
Name:
BDBM50246649
Synonyms:
(R)-ethyl 2-(3-((5-(4-hydroxybenzylamino)-4-(2,2-diphenylacetamido)-5-oxopentylamino)(amino)methylene)ureido)acetate | CHEMBL508974
Type:
Small organic molecule
Emp. Form.:
C32H38N6O6
Mol. Mass.:
602.6807
SMILES:
CCOC(=O)CNC(=O)NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 |r,w:12.12|
Structure:
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