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Target
Cytosolic purine 5'-nucleotidase
Ligand
BDBM50500512
Substrate
n/a
Meas. Tech.
ChEMBL_1544056 (CHEMBL3750564)
Ki
2780000±n/a nM
Citation
 Marton, Z; Guillon, R; Krimm, I; Preeti, na; Rahimova, R; Egron, D; Jordheim, LP; Aghajari, N; Dumontet, C; Périgaud, C; Lionne, C; Peyrottes, S; Chaloin, L Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach. J Med Chem 58:9680-96 (2015) [PubMed]  Article 
Target
Name:
Cytosolic purine 5'-nucleotidase
Synonyms:
3.1.3.5 | 5NTC_HUMAN | NT5B | NT5C2 | NT5CP | PNT5
Type:
PROTEIN
Mol. Mass.:
64964.00
Organism:
Homo sapiens
Description:
ChEMBL_110158
Residue:
561
Sequence:
MSTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEEE
  
Inhibitor
Name:
BDBM50500512
Synonyms:
CHEMBL3746515
Type:
Small organic molecule
Emp. Form.:
C18H13N5O
Mol. Mass.:
315.3287
SMILES:
O=C(Nc1ncnc2[nH]cnc12)c1ccc(cc1)-c1ccccc1
Structure:
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