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Target
Diacylglycerol lipase-alpha
Ligand
BDBM50400831
Substrate
n/a
Meas. Tech.
ChEMBL_1547769 (CHEMBL3756328)
IC50
<10000±n/a nM
Citation
 Janssen, FJ; Baggelaar, MP; Hummel, JJ; Overkleeft, HS; Cravatt, BF; Boger, DL; van der Stelt, M Comprehensive Analysis of Structure-Activity Relationships of ?-Ketoheterocycles as sn-1-Diacylglycerol Lipase ? Inhibitors. J Med Chem 58:9742-53 (2015) [PubMed]  Article 
Target
Name:
Diacylglycerol lipase-alpha
Synonyms:
C11orf11 | DAGLA | DGLA_HUMAN | KIAA0659 | NSDDR | Sn1-specific diacylglycerol lipase alpha
Type:
PROTEIN
Mol. Mass.:
114947.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1449471
Residue:
1042
Sequence:
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFALAAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRNSSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIRTSTPTGHGASPAKQDELVISAR
  
Inhibitor
Name:
BDBM50400831
Synonyms:
CHEMBL220613
Type:
Small organic molecule
Emp. Form.:
C16H18ClNO2
Mol. Mass.:
291.773
SMILES:
Clc1cnc(o1)C(=O)CCCCCCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: