Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50050473
Substrate
n/a
Meas. Tech.
ChEMBL_62110 (CHEMBL674988)
Ki
820±n/a nM
Citation
 Rowley, M; Broughton, HB; Collins, I; Baker, R; Emms, F; Marwood, R; Patel, S; Patel, S; Ragan, CI; Freedman, SB; Leeson, PD 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors. J Med Chem 39:1943-5 (1996) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50050473
Synonyms:
1-(4-Chloro-benzyl)-4-[5-(4-chloro-phenyl)-1H-pyrazol-3-yl]-piperidine | 1-(4-Chloro-benzyl)-4-[5-(4-chloro-phenyl)-2H-pyrazol-3-yl]-piperidine | CHEMBL61080
Type:
Small organic molecule
Emp. Form.:
C21H21Cl2N3
Mol. Mass.:
386.318
SMILES:
Clc1ccc(CN2CCC(CC2)c2cc(n[nH]2)-c2ccc(Cl)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: