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Target
Ribonucleoside-diphosphate reductase subunit M2
Ligand
BDBM50051774
Substrate
n/a
Meas. Tech.
ChEMBL_195255 (CHEMBL796773)
IC50
1700±n/a nM
Citation
 Liu, MC; Lin, TS; Cory, JG; Cory, AH; Sartorelli, AC Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. J Med Chem 39:2586-93 (1996) [PubMed]  Article 
Target
Name:
Ribonucleoside-diphosphate reductase subunit M2
Synonyms:
RIR2_HUMAN | RR2 | RRM2 | Ribonucleoside-diphosphate reductase M2 chain | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit
Type:
PROTEIN
Mol. Mass.:
44868.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_195255
Residue:
389
Sequence:
MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF
  
Inhibitor
Name:
BDBM50051774
Synonyms:
(1Z,N'E)-N'-((3-(allylamino)pyridin-2-yl)methylene)carbamohydrazonothioic acid | CHEMBL87996
Type:
Small organic molecule
Emp. Form.:
C10H13N5S
Mol. Mass.:
235.309
SMILES:
NC(=S)NN=Cc1ncccc1NCC=C |w:5.5|
Structure:
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