Reaction Details Report a problem with these data
Target
UDP-N-acetylbacillosamine N-acetyltransferase
Ligand
BDBM50501659
Substrate
n/a
Meas. Tech.
ChEMBL_1657123 (CHEMBL4006593)
IC50
1000±n/a nM
Citation
 De Schutter, JW; Morrison, JP; Morrison, MJ; Ciulli, A; Imperiali, B Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from Campylobacter jejuni. J Med Chem 60:2099-2118 (2017) [PubMed]  Article 
Target
Name:
UDP-N-acetylbacillosamine N-acetyltransferase
Synonyms:
2.3.1.203 | PGLD_CAMJE | Protein glycosylation D | UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase | UDP-N-acetylbacillosamine N-acetyltransferase | pglD
Type:
PROTEIN
Mol. Mass.:
21152.55
Organism:
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 /NCTC 11168)
Description:
ChEMBL_117403
Residue:
195
Sequence:
MARTEKIYIYGASGHGLVCEDVAKNMGYKECIFLDDFKGMKFESTLPKYDFFIAIGNNEIRKKIYQKISENGFKIVNLIHKSALISPSAIVEENAGILIMPYVVINAKAKIEKGVILNTSSVIEHECVIGEFSHVSVGAKCAGNVKIGKNCFLGINSCVLPNLSLADDSILGGGATLVKNQDEKGVFVGVPAKRM
  
Inhibitor
Name:
BDBM50501659
Synonyms:
CHEMBL4085051
Type:
Small organic molecule
Emp. Form.:
C25H23N3O2S
Mol. Mass.:
429.534
SMILES:
Cc1c(sc2nc(CCc3ccccc3)nc(NC3Cc4ccccc4C3)c12)C(O)=O
Structure:
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