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Target
Sterol O-acyltransferase 1
Ligand
BDBM50053404
Substrate
n/a
Meas. Tech.
ChEMBL_28791 (CHEMBL641701)
IC50
14±n/a nM
Citation
 White, AD; Purchase, CF; Picard, JA; Anderson, MK; Mueller, SB; Bocan, TM; Bousley, RF; Hamelehle, KL; Krause, BR; Lee, P; Stanfield, RL; Reindel, JF Heterocyclic amides: inhibitors of acyl-CoA:cholesterol O-acyl transferase with hypocholesterolemic activity in several species and antiatherosclerotic activity in the rabbit. J Med Chem 39:3908-19 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50053404
Synonyms:
CHEMBL340148 | N-(2,6-Diisopropyl-phenyl)-2-(5-dodecyl-[1,3,4]oxadiazol-2-yl)-2-phenyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C34H49N3O2
Mol. Mass.:
531.7718
SMILES:
CCCCCCCCCCCCc1nnc(o1)C(C(=O)Nc1c(cccc1C(C)C)C(C)C)c1ccccc1
Structure:
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