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Target
Metabotropic glutamate receptor 6
Ligand
BDBM50503456
Substrate
n/a
Meas. Tech.
ChEMBL_1811009 (CHEMBL4310469)
IC50
>30000±n/a nM
Citation
 Childress, ES; Wieting, JM; Felts, AS; Breiner, MM; Long, MF; Luscombe, VB; Rodriguez, AL; Cho, HP; Blobaum, AL; Niswender, CM; Emmitte, KA; Conn, PJ; Lindsley, CW Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu J Med Chem 62:378-384 (2019) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 6
Synonyms:
GPRC1F | GRM6 | GRM6_HUMAN | MGLUR6 | Metabotropic glutamate receptor 6 | glutamate receptor, metabotropic 6 precursor | metabotropic glutamate 6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
95479.26
Organism:
Homo sapiens (Human)
Description:
metabotropic glutamate 6 GRM6 HUMAN::O15303
Residue:
877
Sequence:
MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
  
Inhibitor
Name:
BDBM50503456
Synonyms:
CHEMBL4435396
Type:
Small organic molecule
Emp. Form.:
C20H13F4N5O2
Mol. Mass.:
431.3431
SMILES:
NC(=O)c1cc(-c2ccc(F)cc2)n2nc(COc3ccnc(c3)C(F)(F)F)cc2n1
Structure:
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