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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50273716
Substrate
n/a
Meas. Tech.
ChEMBL_1816329 (CHEMBL4315903)
IC50
24±n/a nM
Citation
 Bhuiyan, NH; Varney, ML; Wiemer, DF; Holstein, SA Novel benzimidazole phosphonates as potential inhibitors of protein prenylation. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Homo sapiens (Human)
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM50273716
Synonyms:
CHEMBL457423 | [2-(Benzoimidazol-1-yl)ethyl]-bisphosphonic acid
Type:
Small organic molecule
Emp. Form.:
C9H12N2O6P2
Mol. Mass.:
306.1489
SMILES:
OP(O)(=O)C(Cn1cnc2ccccc12)P(O)(O)=O
Structure:
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