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Target
Geranylgeranyl transferase type-1 subunit beta
Ligand
BDBM50504718
Substrate
n/a
Meas. Tech.
ChEMBL_1816326 (CHEMBL4315900)
IC50
145000±n/a nM
Citation
 Bhuiyan, NH; Varney, ML; Wiemer, DF; Holstein, SA Novel benzimidazole phosphonates as potential inhibitors of protein prenylation. Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Geranylgeranyl transferase type-1 subunit beta
Synonyms:
GGTase-I-beta | Geranylgeranyl transferase type I subunit beta | Geranylgeranyl transferase type-1 subunit beta | PGTB1_RAT | Pggt1b | Type I protein geranyl-geranyltransferase subunit beta | geranylgeranyltransferase type-I
Type:
PROTEIN
Mol. Mass.:
42414.77
Organism:
Rattus norvegicus
Description:
ChEMBL_105008
Residue:
377
Sequence:
MAATEDDRLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHISS
  
Inhibitor
Name:
BDBM50504718
Synonyms:
CHEMBL4564870
Type:
Small organic molecule
Emp. Form.:
C10H9F2N2O5P
Mol. Mass.:
306.1594
SMILES:
OC(=O)C(Cn1cnc2cc(F)c(F)cc12)P(O)(O)=O
Structure:
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