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Target
Nitroreductase NfsA
Ligand
BDBM50057439
Substrate
n/a
Meas. Tech.
ChEMBL_206006 (CHEMBL840569)
IC50
207000±n/a nM
Citation
 Friedlos, F; Denny, WA; Palmer, BD; Springer, CJ Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy. J Med Chem 40:1270-5 (1997) [PubMed]  Article 
Target
Name:
Nitroreductase NfsA
Synonyms:
Modulator of drug activity A
Type:
PROTEIN
Mol. Mass.:
26851.30
Organism:
Escherichia coli O157:H7
Description:
ChEMBL_206006
Residue:
240
Sequence:
MTPTIELTCGHRSIRHFTDEPISEAQREAIINSARATSSSSFLQCSSIIRITDKALREELVTLTGGQKHVAQAAEFWVFCADFNRHLQICPDAQLGLAEQLLLGVVDTAMMAQNALTAAESLGLGGVYIGGLRNNIEAVTKLLKLPQHVLPLFGLCLGWPADNPDLKPRLPSSILVHENSYQPLDKDALAQYDEQLAEYYLTRGSNNRRDTWSDHIRRTIIKESRPFILDYLHKQGWATR
  
Inhibitor
Name:
BDBM50057439
Synonyms:
Bis-(2-chloro-ethyl)-(5-nitro-thiazol-2-yl)-amine | CHEMBL282461
Type:
Small organic molecule
Emp. Form.:
C7H9Cl2N3O2S
Mol. Mass.:
270.136
SMILES:
[O-][N+](=O)c1cnc(s1)N(CCCl)CCCl
Structure:
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