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Target
NACHT, LRR and PYD domains-containing protein 3
Ligand
BDBM50505850
Substrate
n/a
Meas. Tech.
ChEMBL_1824406 (CHEMBL4324170)
IC50
1.000000±n/a nM
Citation
 Zhang, X; Xu, A; Lv, J; Zhang, Q; Ran, Y; Wei, C; Wu, J Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases. Eur J Med Chem 185:0 (2020) [PubMed]  Article 
Target
Name:
NACHT, LRR and PYD domains-containing protein 3
Synonyms:
Cias1 | Cias1 | Cold autoinflammatory syndrome 1 protein homolog | Cryopyrin | Mast cell maturation-associated-inducible protein 1 | Mmig1 | NACHT, LRR and PYD domains-containing protein 3 | NLRP3_MOUSE | Nalp3 | Nlrp3 | PYRIN-containing APAF1-like protein 1 | Pypaf1
Type:
PROTEIN
Mol. Mass.:
118281.75
Organism:
Mus musculus
Description:
ChEMBL_116758
Residue:
1033
Sequence:
MTSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCIPVPRGQMEKADHLDLATLMIDFNGEEKAWAMAVWIFAAINRRDLWEKAKKDQPEWNDTCTSHSSMVCQEDSLEEEWMGLLGYLSRISICKKKKDYCKMYRRHVRSRFYSIKDRNARLGESVDLNSRYTQLQLVKEHPSKQEREHELLTIGRTKMRDSPMSSLKLELLFEPEDGHSEPVHTVVFQGAAGIGKTILARKIMLDWALGKLFKDKFDYLFFIHCREVSLRTPRSLADLIVSCWPDPNPPVCKILRKPSRILFLMDGFDELQGAFDEHIGEVCTDWQKAVRGDILLSSLIRKKLLPKASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSNELQAREAFRLIQENEVLFTMCFIPLVCWIVCTGLKQQMETGKSLAQTSKTTTAVYVFFLSSLLQSRGGIEEHLFSDYLQGLCSLAADGIWNQKILFEECDLRKHGLQKTDVSAFLRMNVFQKEVDCERFYSFSHMTFQEFFAAMYYLLEEEAEGETVRKGPGGCSDLLNRDVKVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQVRLELLKWIEVKAKAKKLQWQPSQLELFYCLYEMQEEDFVQSAMDHFPKIEINLSTRMDHVVSSFCIKNCHRVKTLSLGFFHNSPKEEEEERRGGRPLDQVQCVFPDTHVACSSRLVNCCLTSSFCRGLFSSLSTNRSLTELDLSDNTLGDPGMRVLCEALQHPGCNIQRLWLGRCGLSHQCCFDISSVLSSSQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLQKLWLVSCCLTSACCQDLALVLSSNHSLTRLYIGENALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSICCSALTSVLKTNQNFTHLYLRSNALGDTGLRLLCEGLLHPDCKLQMLELDNCSLTSHSCWNLSTILTHNHSLRKLNLGNNDLGDLCVVTLCEVLKQQGCLLQSLQLGEMYLNRETKRALEALQEEKPELTIVFEISW
  
Inhibitor
Name:
BDBM50505850
Synonyms:
Dapansutrile | OLT-1177 | OLT1177
Type:
Small organic molecule
Emp. Form.:
C4H7NO2S
Mol. Mass.:
133.169
SMILES:
CS(=O)(=O)CCC#N
Structure:
Search PDB for entries with ligand similarity: