Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 2
Ligand
BDBM50140794
Substrate
n/a
Meas. Tech.
ChEMBL_1824904 (CHEMBL4324668)
IC50
320±n/a nM
Citation
 Che, J; Song, R; Chen, B; Dong, X Targeting CXCR1/2: The medicinal potential as cancer immunotherapy agents, antagonists research highlights and challenges ahead. Eur J Med Chem 185:0 (2020) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50140794
Synonyms:
1-(2-Hydroxy-4-nitro-phenyl)-3-phenyl-urea | 1-(2-hydroxy-4-nitrophenyl)-3-phenylurea | CHEMBL280711
Type:
Small organic molecule
Emp. Form.:
C13H11N3O4
Mol. Mass.:
273.2441
SMILES:
Oc1cc(ccc1NC(=O)Nc1ccccc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: