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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50060325
Substrate
n/a
Meas. Tech.
ChEMBL_48609 (CHEMBL659590)
Ki
>5000±n/a nM
Citation
 Martín-Martínez, M; Bartolomé-Nebreda, JM; Gómez-Monterrey, I; González-Muñiz, R; García-López, MT; Ballaz, S; Barber, A; Fortuño, A; Del Río, J; Herranz, R Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists. J Med Chem 40:3402-7 (1997) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
Cckbr | Cholecystokinin A | Cholecystokinin B receptor | Cholecystokinin receptor | GASR_RAT | Gastrin/cholecystokinin type B receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48980.43
Organism:
RAT
Description:
Cholecystokinin A CCKBR RAT::P30553
Residue:
452
Sequence:
MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGLISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCVQLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPQPLPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50060325
Synonyms:
(2S,8S,8aR)-2-Benzyl-8-[(S)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-oxo-octahydro-indolizine-2-carboxylic acid methyl ester | CHEMBL113699
Type:
Small organic molecule
Emp. Form.:
C33H40N4O6
Mol. Mass.:
588.6939
SMILES:
COC(=O)[C@@]1(Cc2ccccc2)C[C@@H]2[C@H](CCCN2C1=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C
Structure:
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