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Target
Oxysterols receptor LXR-beta
Ligand
BDBM19993
Substrate
n/a
Meas. Tech.
ChEMBL_1839625 (CHEMBL4339840)
EC50
30±n/a nM
Citation
 Saida-Tamiya, K; Tamiya, M; Sekiya, G; Isobe, K; Kitazawa, T; Isaka, N; Matsukawa, A; Kawahara, K; Komuro, A; Ishiguro, M Structural requirements of cholenamide derivatives as the LXR ligands. Bioorg Med Chem Lett 29:1330-1335 (2019) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
Liver X receptor beta | Lxrb | NR1H2_RAT | Nr1h2 | Nuclear receptor subfamily 1 group H member 2 | Orphan nuclear receptor OR-1 | Oxysterols receptor LXR-beta | Ubiquitously-expressed nuclear receptor
Type:
PROTEIN
Mol. Mass.:
49742.14
Organism:
Rattus norvegicus
Description:
ChEMBL_117390
Residue:
446
Sequence:
MSSPTSSLDTPLPGNGSPQPSTSSTSPTIKEEGQETDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKKIQKQQQQQPPPPTEPASGSSARPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM19993
Synonyms:
CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide | T 0901317 | T0901317 | TO-901317 | US10543183, Compound TO901317 | US10669296, Compound TO901317 | US10945978, Compound 1 | [3H]T0901317
Type:
Small organic molecule
Emp. Form.:
C17H12F9NO3S
Mol. Mass.:
481.333
SMILES:
OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Structure:
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