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Target
Prolyl 3-hydroxylase OGFOD1
Ligand
BDBM107704
Substrate
n/a
Meas. Tech.
ChEMBL_1840412 (CHEMBL4340711)
IC50
1400±n/a nM
Citation
 Langley, GW; Abboud, MI; Lohans, CT; Schofield, CJ Inhibition of a viral prolyl hydroxylase. Bioorg Med Chem 27:2405-2412 (2019) [PubMed]  Article 
Target
Name:
Prolyl 3-hydroxylase OGFOD1
Synonyms:
1.14.11.- | 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 | KIAA1612 | OGFD1_HUMAN | OGFOD1 | Prolyl 3-hydroxylase OGFOD1 | TPA1 | Termination and polyadenylation 1 homolog | uS12 prolyl 3-hydroxylase
Type:
PROTEIN
Mol. Mass.:
63220.24
Organism:
Homo sapiens
Description:
ChEMBL_119148
Residue:
542
Sequence:
MNGKRPAEPGPARVGKKGKKEVMAEFSDAVTEETLKKQVAEAWSRRTPFSHEVIVMDMDPFLHCVIPNFIQSQDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKKRREPHISTLRKILFEDFRSWLSDISKIDLESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLVPPWDRSMGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVLSEEKSRLSISGWFHGPSLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTYLDMDYQVQIQEEFEESSEILLKEFLKPEKFTKVCEALEHGHVEWSSRGPPNKRFYEKAEESKLPEILKECMKLFRSEALFLLLSNFTGLKLHFLAPSEEDEMNDKKEAETTDITEEGTSHSPPEPENNQMAISNNSQQSNEQTDPEPEENETKKESSVPMCQGELRHWKTGHYTLIHDHSKAEFALDLILYCGCEGWEPEYGGFTSYIAKGEDEELLTVNPESNSLALVYRDRETLKFVKHINHRSLEQKKTFPNRTGFWDFSFIYYE
  
Inhibitor
Name:
BDBM107704
Synonyms:
US11426393, Compound Table XV.11 | US8598210, 119 | US8598210, Table XV, 10 | US8598210, Table XV, 11 | US8722895, 10: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid trifluoroacetic acid salt | US8722895, 11: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2- carbonyl]amino}-acetic acid | US9598370, Example 00136 | USRE47437, Example {[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C14H11ClN2O4
Mol. Mass.:
306.701
SMILES:
OC(=O)CNC(=O)c1ncc(cc1O)-c1cccc(Cl)c1
Structure:
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