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Target
5-hydroxytryptamine receptor 1D
Ligand
BDBM50065415
Substrate
n/a
Meas. Tech.
ChEMBL_1703 (CHEMBL616910)
IC50
13±n/a nM
Citation
 Castro, JL; Collins, I; Russell, MG; Watt, AP; Sohal, B; Rathbone, D; Beer, MS; Stanton, JA Enhancement of oral absorption in selective 5-HT1D receptor agonists: fluorinated 3-[3-(piperidin-1-yl)propyl]indoles. J Med Chem 41:2667-70 (1998) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41920.63
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
  
Inhibitor
Name:
BDBM50065415
Synonyms:
Benzyl-{(3S,4R)-3-fluoro-1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-propyl]-piperidin-4-yl}-methyl-amine | CHEMBL92207
Type:
Small organic molecule
Emp. Form.:
C26H31FN6
Mol. Mass.:
446.5629
SMILES:
CN(Cc1ccccc1)[C@@H]1CCN(CCCc2c[nH]c3ccc(cc23)-n2cnnc2)C[C@@H]1F
Structure:
Search PDB for entries with ligand similarity: