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Target
Heparanase
Ligand
BDBM50511573
Substrate
n/a
Meas. Tech.
ChEMBL_1845079 (CHEMBL4345506)
IC50
11961±n/a nM
Citation
 Zhu, S; Li, J; Loka, RS; Song, Z; Vlodavsky, I; Zhang, K; Nguyen, HM Modulating Heparanase Activity: Tuning Sulfation Pattern and Glycosidic Linkage of Oligosaccharides. J Med Chem 63:4227-4255 (2020) [PubMed]  Article 
Target
Name:
Heparanase
Synonyms:
Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1
Type:
PROTEIN
Mol. Mass.:
61167.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_327900
Residue:
543
Sequence:
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
  
Inhibitor
Name:
BDBM50511573
Synonyms:
CHEMBL4573010
Type:
Small organic molecule
Emp. Form.:
C20H30N3Na7O33S6
Mol. Mass.:
1193.771
SMILES:
[Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[H][C@]1([#8]-[#6@H]-2-[#6@H](-[#8])-[#6@@H](-[#8]S([#8-])(=O)=O)-[#6@H](-[#8][C@@]3([H])[#6@H](-[#8])-[#6@@H](-[#7]S([#8-])(=O)=O)-[#6@@H](-[#8]-[#6]-[#6]-[#7]S([#8-])(=O)=O)-[#8]-[#6@@H]3-[#6]-[#8]S([#8-])(=O)=O)-[#8]-[#6@@H]-2-[#6](-[#8-])=O)[#8]-[#6@H](-[#6]-[#8]S([#8-])(=O)=O)-[#6@@H](-[#8])-[#6@H](-[#8])-[#6@H]1-[#7]S([#8-])(=O)=O |r|
Structure:
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