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Target
Retinoic acid receptor beta
Ligand
BDBM50066904
Substrate
n/a
Meas. Tech.
ChEMBL_195481 (CHEMBL798903)
EC50
140±n/a nM
Citation
 Benbrook, DM; Subramanian, S; Gale, JB; Liu, S; Brown, CW; Boehm, MF; Berlin, KD Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships. J Med Chem 41:3753-7 (1998) [PubMed]  Article 
Target
Name:
Retinoic acid receptor beta
Synonyms:
HAP | HBV-activated protein | NR1B2 | Nuclear receptor subfamily 1 group B member 2 | RAR-beta | RAR-epsilon | RARB | RARB_HUMAN | Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta | Retinoic acid receptor beta | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50498.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458015
Residue:
455
Sequence:
MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
  
Inhibitor
Name:
BDBM50066904
Synonyms:
4-[(E)-2-(4,4-Dimethyl-chroman-6-yl)-propenyl]-benzoic acid methyl ester | 4-[2-(4,4-Dimethyl-chroman-6-yl)-propenyl]-benzoic acid methyl ester | CHEMBL34464
Type:
Small organic molecule
Emp. Form.:
C22H24O3
Mol. Mass.:
336.4242
SMILES:
COC(=O)c1ccc(\C=C(/C)c2ccc3OCCC(C)(C)c3c2)cc1
Structure:
Search PDB for entries with ligand similarity: