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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50065041
Substrate
n/a
Meas. Tech.
ChEMBL_28169 (CHEMBL644123)
IC50
14±n/a nM
Citation
 Tanaka, A; Terasawa, T; Hagihara, H; Ishibe, N; Sawada, M; Sakuma, Y; Hashimoto, M; Takasugi, H; Tanaka, H Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands. J Med Chem 41:4408-20 (1998) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50065041
Synonyms:
1-Benzyl-1-[3-(2H-pyrazol-3-yl)-benzyl]-3-(2,4,6-trifluoro-phenyl)-urea | CHEMBL78870 | FR-180734
Type:
Small organic molecule
Emp. Form.:
C24H19F3N4O
Mol. Mass.:
436.4291
SMILES:
Fc1cc(F)c(NC(=O)N(Cc2ccccc2)Cc2cccc(c2)-c2cc[nH]n2)c(F)c1
Structure:
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