Reaction Details Report a problem with these data
Target
Cytochrome P450 4B1
Ligand
BDBM50512919
Substrate
n/a
Meas. Tech.
ChEMBL_1850613 (CHEMBL4351237)
IC50
<19953±n/a nM
Citation
 Lemurell, M; Ulander, J; Emtenäs, H; Winiwarter, S; Broddefalk, J; Swanson, M; Hayes, MA; Prieto Garcia, L; Westin Eriksson, A; Meuller, J; Cassel, J; Saarinen, G; Yuan, ZQ; Löfberg, C; Karlsson, S; Sundqvist, M; Whatling, C Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease. J Med Chem 62:4325-4349 (2019) [PubMed]  Article 
Target
Name:
Cytochrome P450 4B1
Synonyms:
1.14.14.1 | CP4B1_HUMAN | CYP4B1 | CYPIVB1 | Cytochrome P450 4B1 | Cytochrome P450-HP
Type:
PROTEIN
Mol. Mass.:
59005.59
Organism:
Homo sapiens
Description:
ChEMBL_119703
Residue:
511
Sequence:
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
  
Inhibitor
Name:
BDBM50512919
Synonyms:
CHEMBL4554158
Type:
Small organic molecule
Emp. Form.:
C22H24FN5O2
Mol. Mass.:
409.4567
SMILES:
Cc1nn(C)cc1NC(=O)[C@@H]1CCCC[C@H]1C(=O)c1ccc(cc1F)-c1cc[nH]n1 |r|
Structure:
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