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Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50068075
Substrate
n/a
Meas. Tech.
ChEMBL_31336 (CHEMBL645542)
IC50
51±n/a nM
Citation
 Fresneau, P; Cussac, M; Morand, JM; Szymonski, B; Tranqui, D; Leclerc, G Synthesis, activity, and molecular modeling of new 2, 4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors. J Med Chem 41:4706-15 (1998) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50068075
Synonyms:
CHEMBL336874 | {5-[1-(1-Bromo-naphthalen-2-yl)-meth-(Z)-ylidene]-2,4-dioxo-thiazolidin-3-yl}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C16H10BrNO4S
Mol. Mass.:
392.224
SMILES:
OC(=O)CN1C(=O)S\C(=C/c2ccc3ccccc3c2Br)C1=O
Structure:
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