Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50514202
Substrate
n/a
Meas. Tech.
ChEMBL_1855858 (CHEMBL4356587)
Ki
0.060000±n/a nM
Citation
Rescourio, G; Gonzalez, AZ; Jabri, S; Belmontes, B; Moody, G; Whittington, D; Huang, X; Caenepeel, S; Cardozo, M; Cheng, AC; Chow, D; Dou, H; Jones, A; Kelly, RC; Li, Y; Lizarzaburu, M; Lo, MC; Mallari, R; Meleza, C; Rew, Y; Simonovich, S; Sun, D; Turcotte, S; Yan, X; Wong, SG; Yanez, E; Zancanella, M; Houze, J; Medina, JC; Hughes, PE; Brown, SP Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an ?-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere. J Med Chem 62:10258-10271 (2019) [PubMed] Article More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Inhibitor
Name:
BDBM50514202
Synonyms:
CHEMBL4446369 | US11274105, Example 179
Type:
Small organic molecule
Emp. Form.:
C40H52ClF2N5O7S
Mol. Mass.:
820.385
SMILES:
[H][C@@]12CC[C@@]1([H])[C@@H](OCCN1CC(F)(F)C1)\C=C\CCN(C)C(=O)C[C@](O)(C(=O)NS(=O)(=O)N(C)C)c1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C2)c3c1 |r,t:18|
Structure:
