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Target
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2/G(I)/G(S)/G(T) subunit beta-1
Ligand
BDBM50444748
Substrate
n/a
Meas. Tech.
ChEMBL_1856735 (CHEMBL4357464)
IC50
5000±n/a nM
Citation
 Li, J; Ge, Y; Huang, JX; Strømgaard, K; Zhang, X; Xiong, XF Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery. J Med Chem 63:5013-5030 (2020) [PubMed]  Article 
Target
Name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2/G(I)/G(S)/G(T) subunit beta-1
Synonyms:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1/gamma-2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1856735
Components:
This complex has 2 components.
Component 1
Name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Synonyms:
GBB1_HUMAN | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | Transducin beta chain 1
Type:
PROTEIN
Mol. Mass.:
37373.57
Organism:
Homo sapiens
Description:
ChEMBL_117032
Residue:
340
Sequence:
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
  
Component 2
Name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Synonyms:
G gamma-I | GBG2_HUMAN | GNG2 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Type:
PROTEIN
Mol. Mass.:
7851.57
Organism:
Homo sapiens
Description:
ChEMBL_117032
Residue:
71
Sequence:
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL
  
Inhibitor
Name:
BDBM50444748
Synonyms:
Aminoquinuride
Type:
Small organic molecule
Emp. Form.:
C21H20N6O
Mol. Mass.:
372.4231
SMILES:
Cc1cc(N)c2cc(NC(=O)Nc3ccc4nc(C)cc(N)c4c3)ccc2n1
Structure:
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