Reaction Details Report a problem with these data
Target
Cytoplasmic tyrosine-protein kinase BMX
Ligand
BDBM164638
Substrate
n/a
Meas. Tech.
ChEMBL_1857786 (CHEMBL4358515)
Kd
22±n/a nM
Citation
 Angst, D; Gessier, F; Janser, P; Vulpetti, A; Wälchli, R; Beerli, C; Littlewood-Evans, A; Dawson, J; Nuesslein-Hildesheim, B; Wieczorek, G; Gutmann, S; Scheufler, C; Hinniger, A; Zimmerlin, A; Funhoff, EG; Pulz, R; Cenni, B Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. J Med Chem 63:5102-5118 (2020) [PubMed]  Article 
Target
Name:
Cytoplasmic tyrosine-protein kinase BMX
Synonyms:
BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK
Type:
Tyrosine-protein kinase
Mol. Mass.:
78030.42
Organism:
Homo sapiens (Human)
Description:
P51813
Residue:
675
Sequence:
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH
  
Inhibitor
Name:
BDBM164638
Synonyms:
BDBM166759 | US10604504, Example 223 | US11623921, Example 223 | US9688629, 123 | US9802915, Example 123 | US9920031, Example 223
Type:
Small organic molecule
Emp. Form.:
C20H23FN4O2
Mol. Mass.:
370.4206
SMILES:
CC#CC(=O)N[C@H]1CCCN(C1)c1c(F)cc(C(N)=O)c2[nH]c(C)c(C)c12 |r|
Structure:
Search PDB for entries with ligand similarity: