Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM50070823
Substrate
n/a
Meas. Tech.
ChEBML_208345
Ki
0.850000±n/a nM
Citation
Isaacs, RC; Cutrona, KJ; Newton, CL; Sanderson, PE; Solinsky, MG; Baskin, EP; Chen, IW; Cooper, CM; Cook, JJ; Gardell, SJ; Lewis, SD; Lucas, RJ; Lyle, EA; Lynch, JJ; Naylor-Olsen, AM; Stranieri, MT; Vastag, K; Vacca, JP C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption. Bioorg Med Chem Lett 8:1719-24 (1999) [PubMed] Article
More Info.:
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Inhibitor
Name:
BDBM50070823
Synonyms:
CHEMBL45480 | N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(2-oxo-3-phenylmethanesulfonylamino-6-propyl-2H-pyridin-1-yl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C24H29N5O4S
Mol. Mass.:
483.583
SMILES:
CCCc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)NCc1ccc(N)nc1C