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Target
Ribosyldihydronicotinamide dehydrogenase [quinone]
Ligand
BDBM50388064
Substrate
n/a
Meas. Tech.
ChEMBL_1863015 (CHEMBL4363871)
IC50
83±n/a nM
Citation
 Hussein, B; Ikhmais, B; Kadirvel, M; Magwaza, RN; Halbert, G; Bryce, RA; Stratford, IJ; Freeman, S Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2). Eur J Med Chem 182:0 (2019) [PubMed]  Article 
Target
Name:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:
Metallothionein-3 | NMOR2 | NQO2 | NQO2_HUMAN | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone]
Type:
Protein
Mol. Mass.:
25917.25
Organism:
Homo sapiens (Human)
Description:
P16083
Residue:
231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
  
Inhibitor
Name:
BDBM50388064
Synonyms:
CHEMBL1237284 | TCMDC-123970
Type:
Small organic molecule
Emp. Form.:
C18H16N4O3
Mol. Mass.:
336.3446
SMILES:
COc1ccc2nc(C)cc(N=NCc3ccc(cc3)[N+]([O-])=O)c2c1 |w:11.10|
Structure:
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