Reaction Details Report a problem with these data
Target
Cereblon isoform 4
Ligand
BDBM50516594
Substrate
n/a
Meas. Tech.
ChEMBL_1866003 (CHEMBL4366978)
Ki
20000±n/a nM
Citation
 Heim, C; Pliatsika, D; Mousavizadeh, F; Bär, K; Hernandez Alvarez, B; Giannis, A; Hartmann, MD De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J Med Chem 62:6615-6629 (2019) [PubMed]  Article 
Target
Name:
Cereblon isoform 4
Synonyms:
Cereblon isoform 4
Type:
PROTEIN
Mol. Mass.:
13620.40
Organism:
Magnetospirillum gryphiswaldense
Description:
ChEMBL_116733
Residue:
124
Sequence:
MPLDAGGQNSTQMVLAPGASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPAD
  
Inhibitor
Name:
BDBM50516594
Synonyms:
CHEMBL4447985
Type:
Small organic molecule
Emp. Form.:
C15H22F3N3O6
Mol. Mass.:
397.3469
SMILES:
OC(=O)C(F)(F)F.NC[C@H]1CC[C@@H](COC(=O)NC2CC(=O)NC2=O)CC1 |r,wU:12.11,9.7,(19.63,-24,;20.96,-23.24,;20.96,-21.7,;22.3,-24,;23.64,-23.24,;22.3,-25.54,;23.63,-24.78,;6.82,-18.15,;8.36,-18.16,;9.12,-19.5,;10.66,-19.51,;11.43,-20.84,;10.65,-22.16,;11.41,-23.49,;12.96,-23.49,;13.73,-24.83,;15.27,-24.83,;12.96,-26.16,;13.73,-27.5,;15.26,-27.66,;15.58,-29.17,;16.99,-29.79,;14.25,-29.94,;13.11,-28.91,;11.6,-29.23,;9.11,-22.17,;8.34,-20.83,)|
Structure:
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