Reaction Details Report a problem with these data
Target
Cereblon isoform 4
Ligand
BDBM50516599
Substrate
n/a
Meas. Tech.
ChEMBL_1866003 (CHEMBL4366978)
Ki
5000±n/a nM
Citation
 Heim, C; Pliatsika, D; Mousavizadeh, F; Bär, K; Hernandez Alvarez, B; Giannis, A; Hartmann, MD De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J Med Chem 62:6615-6629 (2019) [PubMed]  Article 
Target
Name:
Cereblon isoform 4
Synonyms:
Cereblon isoform 4
Type:
PROTEIN
Mol. Mass.:
13620.40
Organism:
Magnetospirillum gryphiswaldense
Description:
ChEMBL_116733
Residue:
124
Sequence:
MPLDAGGQNSTQMVLAPGASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLRLIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRLAEGPAD
  
Inhibitor
Name:
BDBM50516599
Synonyms:
CHEMBL4454711
Type:
Small organic molecule
Emp. Form.:
C16H24F3N3O6
Mol. Mass.:
411.3735
SMILES:
OC(=O)C(F)(F)F.NC[C@H]1CC[C@@H](COC(=O)NC2CCC(=O)NC2=O)CC1 |r,wU:12.11,9.7,(55.91,-23.33,;57.24,-22.57,;57.24,-21.03,;58.58,-23.33,;59.91,-22.57,;58.58,-24.88,;59.91,-24.11,;43.1,-17.49,;44.64,-17.49,;45.4,-18.82,;46.94,-18.83,;47.71,-20.16,;46.92,-21.49,;47.7,-22.82,;49.24,-22.82,;50.01,-24.16,;51.55,-24.16,;49.24,-25.49,;50.01,-26.83,;51.55,-26.82,;52.32,-28.17,;51.54,-29.49,;52.31,-30.83,;50,-29.49,;49.24,-28.16,;47.7,-28.16,;45.39,-21.5,;44.63,-20.16,)|
Structure:
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