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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM23408
Substrate
n/a
Meas. Tech.
ChEMBL_1869611 (CHEMBL4370677)
IC50
340±n/a nM
Citation
 Zhao, L; Yuan, X; Wang, J; Feng, Y; Ji, F; Li, Z; Bian, J A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs. Bioorg Med Chem 27:677-685 (2019) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM23408
Synonyms:
2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-chromen-4-one | CHEMBL413552 | Quercetagetin | Quercetagetin (24) | US11759530, Compound Table1.8
Type:
flavonol
Emp. Form.:
C15H10O8
Mol. Mass.:
318.2351
SMILES:
Oc1ccc(cc1O)-c1oc2cc(O)c(O)c(O)c2c(=O)c1O
Structure:
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