Reaction Details Report a problem with these data
Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50072395
Substrate
n/a
Meas. Tech.
ChEMBL_210510 (CHEMBL811905)
Ki
6500±n/a nM
Citation
 Chu, W; Perlman, JH; Gershengorn, MC; Moeller, KD Thyrotropin releasing hormone analogs: a building block approach to the construction of tetracyclic peptidomimetics. Bioorg Med Chem Lett 8:3093-6 (1999) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRH-R | TRHR_MOUSE | Thyroliberin receptor | Trhr | thyrotropin-releasing hormone R1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44568.52
Organism:
MOUSE
Description:
thyrotropin-releasing hormone R1 TRHR MOUSE::P21761
Residue:
393
Sequence:
MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
  
Inhibitor
Name:
BDBM50072395
Synonyms:
1-[3-cyclohexyl-2-(5-oxotetrahydro-1H-2-pyrrolylcarboxamido)propanoyl]tetrahydro-1H-2-pyrrolecarboxamide | CHEMBL2370383
Type:
Small organic molecule
Emp. Form.:
C19H30N4O4
Mol. Mass.:
378.4659
SMILES:
[H][C@]1(CCC(=O)N1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N1CCC[C@H]1C(N)=O
Structure:
Search PDB for entries with ligand similarity: