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Target
Chloride anion exchanger
Ligand
BDBM50519185
Substrate
n/a
Meas. Tech.
ChEMBL_1874150 (CHEMBL4375439)
IC50
300±n/a nM
Citation
 Lee, S; Cil, O; Haggie, PM; Verkman, AS 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. J Med Chem 62:8330-8337 (2019) [PubMed]  Article 
Target
Name:
Chloride anion exchanger
Synonyms:
Chloride anion exchanger | Down-regulated in adenoma | Dra | Protein DRA | S26A3_MOUSE | Slc26a3 | Solute carrier family 26 member 3
Type:
PROTEIN
Mol. Mass.:
83598.25
Organism:
Mus musculus
Description:
ChEMBL_119253
Residue:
757
Sequence:
MIEAIGNQYVVARPVYSTKTFGEEFKKTHRHHKTFLDHLKGCCSCSSQKAKKIALSLFPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLGTSRHISVGPFPVLSMMVGVVVTRVVSDPNASSELSSSSTENDSFIEEKVMVAASVTVLSGIIQLLLGVLQVGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLPVPAYSDPFSIFKVLESVFTQIQKTNIADLVTSVIILVVVFVFKEINQRYRSKLPVPIPIELIMTVIATGVSYGCNFEDRFGVAVVGNMSLGFQPPITPSVEVFQDTIGDSFGIAIVGFAVAFSVASVYSLKYDYPIDGNQELIALGVSNIFTGAFKGFAGSTALSRSGVQESTGGKTQVAGLLSAVIVLIVIVAIGFLLQPLQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTFIFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYAEVYEPEGVKIFRCPSPIYFANIGFFKQKLIDAVGFSPLRILRKRNKALKKIRKLQKRGLIQMTPKGFICTSDGFKDSDEELDNNQIEELDQPINTTDLPFDIDWNGDLPLNITIPKISLHSLILDFSAVSFLDVSSMRGLRTILQEFIRIKVDVYIVGTDDDFIDKLARCEFFDDEVTDSIFFLTIHDAILHILMKKDYSTSKFNSSQEKERKFDFTINTNGGLRNRECQVPVETKF
  
Inhibitor
Name:
BDBM50519185
Synonyms:
CHEMBL4445315
Type:
Small organic molecule
Emp. Form.:
C19H15F3O6
Mol. Mass.:
396.314
SMILES:
Cc1c(OCc2ccc(o2)C(F)(F)F)ccc2c(C)c(CC(O)=O)c(=O)oc12
Structure:
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