Reaction Details Report a problem with these data
Target
Transient receptor potential cation channel subfamily V member 4
Ligand
BDBM85747
Substrate
n/a
Meas. Tech.
ChEMBL_1875693 (CHEMBL4377087)
IC50
>20000±n/a nM
Citation
 Sharma, S; Hopkins, CR Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases. J Med Chem 62:7589-7602 (2019) [PubMed]  Article 
Target
Name:
Transient receptor potential cation channel subfamily V member 4
Synonyms:
TRPV4_MOUSE | Trp12 | Trpv4 | Vrl2 | Vroac
Type:
PROTEIN
Mol. Mass.:
98032.61
Organism:
Mus musculus
Description:
ChEMBL_1514430
Residue:
871
Sequence:
MADPGDGPRAAPGEVAEPPGDESGTSGGEAFPLSSLANLFEGEEGSSSLSPVDASRPAGPGDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHPSDNKRWRRKVVEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLSFLLTHKKRLTDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTSLHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFPDSNLETVLNNDGLSPLMMAAKTGKIGVFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEVSVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTSIKDLFTKKCPGVNSLFVDGSFQLLYFIYSVLVVVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCDEDQSNCTVPTYPACRDSETFSAFLLDLFKLTIGMGDLEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLGIINEDPGKSEIYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSSADEVVVPLDNLGNPNCDGHQQGYAPKWRTDDAPL
  
Inhibitor
Name:
BDBM85747
Synonyms:
CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 | clemizole
Type:
Small organic molecule
Emp. Form.:
C19H20ClN3
Mol. Mass.:
325.835
SMILES:
Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1
Structure:
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