Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 5
Ligand
BDBM85747
Substrate
n/a
Meas. Tech.
ChEMBL_1875685 (CHEMBL4377079)
IC50
1100±n/a nM
Citation
 Sharma, S; Hopkins, CR Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases. J Med Chem 62:7589-7602 (2019) [PubMed]  Article 
Target
Name:
Short transient receptor potential channel 5
Synonyms:
CCE2 | Capacitative calcium entry channel 2 | Short transient receptor potential channel 5 | TRP-5 | TRPC5_MOUSE | Transient receptor protein 5 | Trp-related protein 5 | Trp5 | Trpc5 | Trrp5 | mTRP5
Type:
PROTEIN
Mol. Mass.:
111470.55
Organism:
Mus musculus
Description:
ChEMBL_119231
Residue:
975
Sequence:
MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLSAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRKPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRRSLSTSSADFSQRDDTNDGSGGARAKSKSVSFNVGCKKKACHGAPLIRTVPRASGAQGKPKSESSSKRSFMGPSFKKLGLFFSKFNGQTSEPTSEPMYTISDGIAQQHCMWQDIRYSQMEKGKAEACSQSQMNLGEVELGEIRGAAARSSECPLACSSSLHCASGICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL
  
Inhibitor
Name:
BDBM85747
Synonyms:
CAS_442-52-4 | CLEMIZOLE HYDROCHLORIDE | NSC_2782 | clemizole
Type:
Small organic molecule
Emp. Form.:
C19H20ClN3
Mol. Mass.:
325.835
SMILES:
Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1
Structure:
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