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Target
Alpha-galactosidase A
Ligand
BDBM50073993
Substrate
n/a
Meas. Tech.
ChEBML_34260
IC50
805000±n/a nM
Citation
 Schaller, C; Demange, R; Picasso, S; Vogel, P Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative. Bioorg Med Chem Lett 9:277-8 (1999) [PubMed]  Article 
Target
Name:
Alpha-galactosidase A
Synonyms:
AGAL_HUMAN | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A) | GLA | INN=Agalsidase | Melibiase
Type:
Protein
Mol. Mass.:
48760.21
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
429
Sequence:
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
  
Inhibitor
Name:
BDBM50073993
Synonyms:
(3aS,6S,6aS)-3-Hydroxymethyl-3a,5,6,6a-tetrahydro-furo[2,3-d]isoxazole-5,6-diol | CHEMBL96060
Type:
Small organic molecule
Emp. Form.:
C6H9NO5
Mol. Mass.:
175.1394
SMILES:
OCC1=NO[C@H]2[C@H](O)C(O)O[C@@H]12 |t:2|
Structure:
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