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Target
Peroxisomal membrane protein PEX14
Ligand
BDBM50520195
Substrate
n/a
Meas. Tech.
ChEMBL_1879207 (CHEMBL4380601)
EC50
3480±n/a nM
Citation
 Dawidowski, M; Kalel, VC; Napolitano, V; Fino, R; Schorpp, K; Emmanouilidis, L; Lenhart, D; Ostertag, M; Kaiser, M; Kolonko, M; Tippler, B; Schliebs, W; Dubin, G; Mäser, P; Tetko, IV; Hadian, K; Plettenburg, O; Erdmann, R; Sattler, M; Popowicz, GM Structure-Activity Relationship in Pyrazolo[4,3- J Med Chem 63:847-879 (2020) [PubMed]  Article 
Target
Name:
Peroxisomal membrane protein PEX14
Synonyms:
PEX14 | PEX14_HUMAN | PTS1 receptor-docking protein | Peroxin-14 | Peroxisomal membrane anchor protein PEX14
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41218.98
Organism:
Homo sapiens (Human)
Description:
O75381
Residue:
377
Sequence:
MASSEQAEQPSQPSSTPGSENVLPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGEGVVDVKGQVRMEVQGEEEKREDKEDEEDEEDDDVSHVDEEDCLGVQREDRRGGDGQINEQVEKLRRPEGASNESERD
  
Inhibitor
Name:
BDBM50520195
Synonyms:
CHEMBL4591370
Type:
Small organic molecule
Emp. Form.:
C35H39N5O3
Mol. Mass.:
577.7159
SMILES:
COc1ccc(CN2Cc3c(C2)n(CCNC(C)(C)CO)nc3C(=O)NCc2cccc3ccccc23)c2ccccc12
Structure:
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