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Target
Monoglyceride lipase
Ligand
BDBM50520892
Substrate
n/a
Meas. Tech.
ChEMBL_1882395 (CHEMBL4383894)
IC50
112±n/a nM
Citation
 Alapafuja, SO; Malamas, MS; Shukla, V; Zvonok, A; Miller, S; Daily, L; Rajarshi, G; Miyabe, CY; Chandrashekhar, H; Wood, J; Tyukhtenko, S; Straiker, A; Makriyannis, A Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment. Bioorg Med Chem 27:55-64 (2019) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL)
Type:
Enzyme
Mol. Mass.:
33505.38
Organism:
Rattus norvegicus (Rat)
Description:
Q8R431
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP
  
Inhibitor
Name:
BDBM50520892
Synonyms:
CHEMBL4548730
Type:
Small organic molecule
Emp. Form.:
C26H23FN2O2
Mol. Mass.:
414.4714
SMILES:
Fc1ccc(cc1OC(=O)N1CCC(CC1)C(c1ccccc1)c1ccccc1)C#N
Structure:
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