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Target
Thromboxane A2 receptor
Ligand
BDBM50075636
Substrate
n/a
Meas. Tech.
ChEMBL_209591 (CHEMBL814726)
IC50
110±n/a nM
Citation
 Soyka, R; Guth, BD; Weisenberger, HM; Luger, P; Müller, TH Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors. J Med Chem 42:1235-49 (1999) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50075636
Synonyms:
(E)-6-[3-(N'-Benzoyl-N''-cyclopentyl-guanidino)-phenyl]-6-pyridin-3-yl-hex-5-enoic acid | CHEMBL21303
Type:
Small organic molecule
Emp. Form.:
C30H32N4O3
Mol. Mass.:
496.6001
SMILES:
OC(=O)CCCC=C(c1cccnc1)c1cccc(c1)N=C(NC1CCCC1)NC(=O)c1ccccc1 |w:20.21,6.5|
Structure:
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